Leipzig's 2-1 loss at Dortmund last week, their first in the league this season, has given Vincent Kompany's Bayern the chance to grow their lead at the top of the table.
The international break seems to have come at just the right time for Bayern Munich, allowing the 2020 treble winners a chance to regroup under head coach Vincent Kompany.
Bayern Munich had not lost a Champions League group game since 2017 until a 1-0 defeat to Aston Villa on Wednesday night.
Bayern remain top of the Bundesliga table, two points ahead of RB Leipzig and three ahead of Leverkusen.
Bayern Munich come into the season on the back of a first trophyless campaign in 11 years.
Leverkusen have not lost a match in Germany in May 2023.
Thomas Muller bagged a brace, while Harry Kane and Kingsley Coman also got on the scoresheet.
Bayern Munich have been searching for months but have been knocked back by several candidates after their first trophyless season for 12 years.
Manchester City kick-off their Premier League title defense away at newly-promoted Burnley at Turf Moor on Saturday.
Burnley still have seven games to play, making their promotion the quickest of the Championship era.