Vincent Kompany signed off with victory in the FA Cup final on Saturday, where Manchester City thrashed Watford 6-0 to complete a domestic treble.
Manchester City moved back one point clear of Liverpool despite not being at their fluent best.
Kompany, 32, has not played since suffering a groin injury in the team's 0-0 friendly draw with Portugal on June 2.
2018 World Cup: FIFA rules stipulate injured players can be replaced up to 24 hours before a nation's first group phase game.
Manchester City won the first trophy of the Pep Guardiola era on Sunday, thumping a disappointing Arsenal 3-0 in the League Cup final at Wembley.
Vincent Kompany marked his return to the Manchester City line-up with a rare goal as his side climbed to third in the Premier League with a 3-0 win at Southampton on Saturday.
Vincent Kompany has been dogged by a series of injuries for most of the season and the defender limped out of Manchester City's Champions League semi-final defeat to Real Madrid
Manchester City qualified for the Champions League after a 0-0 draw at home to Dynamo Kiev, which saw them progress 3-1 on aggregate.
Vincent Kompany has been out of action since a Manchester City F.C.'s 4-1 win over Sunderland on Boxing Day when he suffered the recurrence of a calf injury that has dogged the defender in recent seasons.
Leicester City's 15-goal top scorer Jamie Vardy is expected to be fully fit for the clash against Manchester City.
Vincent Kompany came off the bench in the 4-1 win on Saturday over Sunderland but unfortunately lasted less than 10 minutes before despondently walking off with a calf injury.
Manchester City F.C. are currently at the third position in the English Premier League with 32 points in 17 matches. City captain Vincent Kompany, down with a calf injury, missed the last eight matches but is expected to be back against Sunderland on Saturday
While Vincent Kompany is suffering from a calf injury, David Silva has been out for six weeks due to an ankle injury.
Vincent Kompany recently ignored Manchester City manager Manuel Pellegrini's warning that he should not play for Belgium in a Euro 2016 qualifier.
Vincent Kompany was called up for international duty despite missing Manchester City's last five games with a calf injury.
Manchester City F.C. captain Vincent Kompany was forced off the pitch in the 75th minute during his side's 2-1 defeat to Juventus in Champions League.
Sergio Aguero, Vincent Kompany and Fernandinho scored a goal each as Manchester City F.C. crushed Chelsea F.C. 3-0.
Manchester City vs Chelsea, Barclays English Premier League (EPL) - live score, news updates, live football match report and result from Etihad Stadium on Sunday.