Tottenham's Clint Dempsey and AZ Alkmaar's Jozy Altidore were selected on Monday in the US squad for the crucial North American final-round World Cup 2014 qualifying opener at Honduras on Wednesday.
Mexico, Jamaica, Costa Rica and Panama are also competing for three berths at stake in Confederation of North, Central American and Caribbean Association Football (CONCACAF) qualifying.
The fourth-place team will face the Oceania winner for another berth in next year's World Cup finals in Brazil.
"We want to have a sense of urgency right from the start of the final Round," US coach Jurgen Klinsmann said. "We have a lot of respect for Honduras, but our message to the team is that we are going there to get three points.
"One thing we learned from the semi-final round is that you have to bring the right mentality to play in the tough games on the road and I'm confident we are ready to do that."
Goalkeepers: Brad Guzan (Aston Villa/EMG), Tim Howard (Everton/ENG), Sean Johnson (Chicago Fire)
Defenders: Matt Besler (Sporting Kansas City), Carlos Bocanegra (Racing Santander/ESP), Geoff Cameron (Stoke City/ENG), Edgar Castillo (Club Tijuana/MEX), Timmy Chandler (Nuremberg/GER), Brad Evans (Seattle Sounders), Omar Gonzalez (LA Galaxy), Fabian Johnson (Hoffenheim/GER), Michael Parkhurst (Augsburg/GER)
Midfielders: Michael Bradley (AS Roma/ITA), Brad Davis (Houston Dynamo), Maurice Edu (Bursaspor/TUR), Jermaine Jones (Schalke 04/GER), Sacha Kljestan (Anderlecht/BEL), Jose Torres (Tigres), Danny Williams (Hoffenheim/GER), Graham Zusi (Sporting Kansas City)
Forwards: Jozy Altidore (AZ Alkmaar/NED), Clint Dempsey (Tottenham Hotspur/ENG), Herculez Gomez (Santos), Eddie Johnson (Seattle Sounders).