Rohit Sharma smashed his way to his 21st T20I half-century before walking off the field due to some discomfort in his calf.
Ireland held their nerve in a nail-biting final over to pull off a four-run win over world champions West Indies.
Nicholas Pooran top-scored for the West Indies with 52 while Hayden Walsh Jr's knock of 46 saw them beat Ireland and take a 2-0 series lead.
Live Cricket Score: AFG Vs IRE 2nd T20I: Afghanistan lead the three-match series 1-0.
Paul Stirling and veteran Trent Johnston starred for Ireland as Afghanistan were bowled out for 157, chasing a mammoth 225 for a win in Abu Dhabi.
Ireland made 268-5 in their innings, but Michael Rippon stole the show for the Dutch by smashing the last two balls of the match for four and six to bring the Netherlands level off their 50 overs.
Ireland and Afghanistan served up a blistering classic in the final of the World Twenty20 Qualifier in Dubai, putting to rest any fears that the game would be an anti-climax after both teams had already sealed their spot in the World Twenty20 to be held later this year.
Paul Stirling starred with both the bat and ball as Ireland beat Kenya by eight wickets in the second Twenty20 international match at the Mombasa Sports Club grounds on Thursday.