Two-time winner Rafael Nadal and defending women's champion Petra Kvitova start their Wimbledon campaigns on Tuesday while veterans Andy Roddick and Lleyton Hewitt ride an emotional wave of support.
Nadal, fresh from his record-breaking seventh French Open title, tackles Brazil's Thomaz Bellucci on Centre Court after Kvitova, who win her maiden Grand Slam event at the All England Club last year, faces Akgul Amanmuradova of Uzbekistan.
Britain's Andy Murray, semi-finalist for the last two years, takes on Russian veteran Nikolay Davydenko.
Lleyton Hewitt, the champion in 2002 but needing a wildcard to play this year, faces French fifth seed Jo-Wilfried Tsonga, who beat Roger Federer on to his way to the semi-finals last year.
Roddick, three times a runner-up, begins against Britain's Jamie Baker buoyed by winning the Eastbourne grasscourt title last weekend.
Also in action on day two are women's second seed Victoria Azarenka who faces America's Irina Falconi and fellow former number one Caroline Wozniacki who meets Tamira Paszek, the women's champion in Eastbourne.