With Thandi's exit, the Indian challenge in the singles draw came to an end
In other matches, Katarzyna Kawa of Poland eliminated Australian Astra Sharma 6-4, 6-3 and Nao Hibino of Japan thrashed Jana Fett 6-0, 6-4 in a battle of qualifiers to advance to the round of 16.
Former world number one Andy Murray and Eugenie Bouchard, a semi-finalist in Paris six years ago, were handed wild card entries for the French Open which begins on September 27.
Eugenie Bouchard requested her fans to stop sending "dating resumes" following one of her tweets that read "quarantine would be a lot more fun with a boyfriend".
Eugenie Bouchard had gone on a blind date after losing a Super Bowl bet in 2017.
This time last year, Bianca Andreescu was sat at home nursing an injury and coming to terms with a second successive failed attempt at making the US Open main draw.
Russia's Sharapova -- the world's highest-paid female athlete for more than a decade until last year, according to Forbes -- won on Wednesday on her comeback after testing positive for meldonium.
John Goehrke won his dream date with Eugenie Bouchard thanks to the New England Patriots' record-setting rally to defeat the Atlanta Falcons in Super Bowl 51 earlier this month.
Eugenie Bouchard learned the hard way on Sunday never to bet against superstar quarterback Tom Brady and the New England Patriots, who rallied from a 25-point deficit to defeat the Atlanta Falcons 34-28 in overtime to claim the NFL crown.
The mosquito-transmitted Zika virus causes severe illness and has been linked to birth defects, a factor causing Eugenie Bouchard the greatest concern