Daniil Medvedev continued his Rome title defence with Monday's hard-fought 7-6 (7/5), 2-6, 7-5 win over qualifier Hamad Medjedovic
The Italian had lost to the Russian in the Miami final last year but rallied from two sets down to beat him in the Australian Open final in January.
Jannik Sinner will next face the winner of Wednesday's other quarter-final between defending champion Daniil Medvedev and Chile's Nicolas Jarry.
Defending Miami Open champion Daniil Medvedev and top seed Carlos Alcaraz marched into the quarter-finals of the tournament on Tuesday with convincing victories.
World number two Carlos Alcaraz cruised home in a 7-6 (7/5), 6-1 victory over Daniil Medvedev on Sunday to win a second straight Indian Wells ATP title
Emma Navarro's victory continues a strong season for the 22-year-old, who won the WTA title in Hobart and reached the semi-finals in Auckland and San Diego.
Daniil Medvedev raced to victory over Alejandro Davidovich Fokina on Thursday to reach the Dubai semi-finals and continue his excellent start to the year.
Jannik Sinner stormed back from two sets down to beat Daniil Medvedev in a gruelling five-set Australian Open final on Sunday, winning his first Grand Slam.
Australia Open Final Highlights: Jannik Sinner reistered a comeback victory over Daniil Medvedev to claim his maiden Grand Slam.
Daniil Medvedev battled into a third Australian Open final Friday with a come-from-behind five-set defeat of Alexander Zverev to set up a title match against Jannik Sinner.