Medvedev, who lifted the title in 2020, did not face a single break point and broke De Minaur's serve three times.
Daniil Medvedev is still searching for his first ATP tournament victory this year after the world number five lost to Australia's Alexei Popyrin for the first time in his career at the Paris Masters
Both Daniil Medvedev and Stefanos Tsitsipas served sweet revenge at the Shanghai Masters on Friday, vanquishing old foes in straight sets as they progressed through to the third round.
Carlos Alcaraz and Daniil Medvedev also made winning starts to their China Open campaigns.
World number one Jannik Sinner reached his first US Open semi-final with a four-set victory over 2021 champion and two-time runner-up Daniil Medvedev.
World number one Jannik Sinner and former champion Daniil Medvedev set up a US Open quarter-final showdown on Monday
Having clinched his fourth Grand Slam and back-to-back Wimbledon titles at the age of just 21, Spain's tennis star Carlos Alcaraz has the world at his feet.
Defending champion Carlos Alcaraz outlasted Daniil Medvedev 6-7, 6-3, 6-4, 6-4 in the men's singles semifinal of the Wimbledon 2024 to enter the title-decider.
After leading Team India to T20 World Cup 2024 title, skipper Rohit Sharma has switched to vacation mode with his family in London
Daniil Medvedev vs Carlos Alcaraz Live Streaming Wimbledon 2024 Men's Singles Semi-Final Live Telecast: When And Where To Watch