Juan Carlos Ferrero knocked out the last remaining seed at the Mercedes Cup when he beat No. 3 Mikhail Youzhny 6-7 (6), 6-2, 6-2 in the second round on Thursday.
Earlier, wild card Lukasz Kubot of Poland came back to upset eighth-seeded Guillermo Garcia-Lopez of Spain 4-6, 6-4, 6-3 for a place in the quarterfinals.
Garcia-Lopez and Youzhny, who won the clay-court tournament in 2002 for his first title, were the only two seeded players to make it into the second round.
Jeremy Chardy of France, the 2009 champion, also went out, losing to Santiago Giraldo of Colombia. Chardy won the first set when the match was suspended a day earlier because of rain, but Giraldo rallied when the match resumed on Thursday to win 1-6, 7-5, 6-4.
Qualifier Pavol Cervenak of Slovakia beat Victor Hanescu of Romania 6-3, 7-6 (6). Hanescu had defeated top-seeded Gael Monfils in the first round.
Federico del Bonis of Argentina, another qualifier, defeated Sergiy Stakhovsky of Ukraine 6-4, 6-3.
Wild card Cedrik-Marcel Stebe, who comes from near Stuttgart, upset French Open quarterfinalist Fabio Fognini of Italy 7-6 (5), 6-4. Stebe posted his first win on the tour in the first round by upsetting Nikolay Davydenko.
Marcel Granollers of Spain defeated Benoit Paire of France 6-4, 7-5.