Fifth seed Jo-Wilfried Tsonga completed a 6-2, 4-6, 6-2, 6-1 win over German qualifier Cedrik-Marcel Stebe, while sixth seed David Ferrer of Spain coasted past Benoit Paire of France 6-3, 6-3, 6-2 in the French Open second round.
Another South American claycourter to make it through was 13th seed Juan Monaco of Argentina who stopped Lukas Rosol of the Czech Republic 7-6 (7/4), 6-0, 7-6 (7/5).
Rising Canadian player Milos Raonic defeated qualifier Jesse Levine 6-4, 7-5, 6-2 meaning that five days into the tournament John Isner is the only surviving American player.
Isner is due on court later on Thursday against Frenchman Paul-Henri Mathieu, aiming to reach the third round at Roland Garros for just the second time in his career.
The Spaniard, who will turn 25 during the tournament, is seeking to win a record seventh French Open title taking him out of tie for the most wins he currently shares with Bjorn Borg.