FA Cup: Scott McTominay's extra-time winner against West Ham saw Manchester United edge through to the quarter-finals.
Manchester City on Wednesday announced the signing of Bournemouth defender Nathan Ake on a five-year deal
Bournemouth's rebuild in the Championship will take place without Eddie Howe, who told supporters it was the right time to leave.
Watford and Bournemouth were relegated from the Premier League but there was joy for Aston Villa, who avoided the drop by the skin of their teeth.
In a thrilling conclusion, top four places, Europa League berths, relegation spots and the Golden Boot have to be settled in the last round of matches.
Manchester United and Leicester face each other in a shootout for a place in the Champions League next season with Chelsea also hoping to secure their place in the top four.
Arsenal ended Liverpool's bid to set a new Premier League points record with a 2-1 win over the champions, while Manchester City pushed Bournemouth closer to relegation with a 2-1 victory on Wednesday.
Bournemouth's first win in 10 games, a drought stretching back to February 1, moved them to within three points of 17th placed Watford, with three games left.
The Premier League confirmed that Manchester United and Southampton should not have been given penalties, but Tottenham should have been awarded one.
Manchester United were far too strong for lowly Aston Villa, but their opening goal came from a dubious penalty that left the hosts fuming.
Marcus Rashford, Anthony Martial, Bruno Fernandes and Mason Greenwood, who netted twice, were all on the scoresheet to lift Manchester United one point above fifth-placed Chelsea.
Ole Gunnar Solskjaer said the "sky's the limit" for Manchester United forward Mason Greenwood, describing the 18-year-old as "way ahead" of where he was at the same age.
Aaron Ramsdale was one of two positive cases from the second round of testing carried out by Premier League clubs as they gear up for a return to action next month.
The Premier League announced Saturday that there were positive tests at two clubs out of 996 tests conducted on Tuesday, Thursday and Friday.
The prolific duo of Mohamed Salah and Sadio Mane quickly turned the game around and a heroic goal-line clearance from James Milner in the second half secured the win to open a 25-point lead at the top of the table.
Liverpool will look to extend their 22-point lead at the top of the table when they take on Bournemouth at home.
Liverpool remain 22 points clear and well on course for a first league title in 30 years.
Chelsea salvaged a 2-2 draw at struggling Bournemouth as West Ham boosted their chances of survival with a 3-1 win over Southampton.