Neymar's returning form will be a key factor for the team, which lost influential right-back Dani Alves to a knee injury last week.
Neymar broke a bone in his right foot on February 26 during PSG's 3-0 win over Marseille.
Neymar said he expects to be in "better shape" for the 2018 World Cup in Russia than he was before his foot injury.
Brazilian legend Pele says he is confident about Brazil's chances at the upcoming World Cup and expects injured star Neymar to be fully fit to lead the side in Russia
Barcelona coach Ernesto Valverde has dismissed reports suggesting Neymar could leave Paris Saint-Germain and return to the Catalan giant as "fantasy".
Neymar already regrets moving to Paris Saint-Germain and is seeking a shock return to Barcelona, according to reports in the Spanish media on Friday.
Angel Di Maria, a Champions League winner with Madrid in 2014, is set to replace Neymar in the home line-up before a sell-out crowd of around 47,000 at the Parc des Princes.
Dani Alves is confident that Paris Saint-Germain have what it takes to beat Real Madrid in their Champions League showdown in Neymar's absence.
Neymar was released on Sunday after undergoing an operation on Saturday morning to repair a fracture of the fifth metatarsal bone in his right foot.
Brazilian superstar Neymar will undergo surgery on his fractured foot in Brazil as early as Thursday, ruling the world's most expensive footballer out of Paris Saint-Germain's do-or-die Champions League clash with Real Madrid.
Paris Saint-Germain forward Neymar faces "at least six weeks" out with a fractured bone in his foot and will miss next week's return leg of the Champions League last-16 tie against Real Madrid
Brazil's national team doctor Rodrigo Lasmar has travelled to France to assess the foot injury suffered by Paris Saint-Germain (PSG) forward Neymar Jr
PSG trail 3-1 from the last 16 first leg in Madrid two weeks ago and the loss of Neymar would be a huge blow to their chances of overturning that deficit.
The chances of Neymar returning to fitness in time to face Real Madrid in the Champions League now appear extremely slim.
Neymar was stretchered off in tears towards the end of PSG's 3-0 victory over their great rivals at the Parc des Princes, having innocuously rolled his right ankle
Philippe Coutinhos move to Barcelona from Liverpool for a staggering 160 million Euros has helped him spiral as the second most expensive transfer in the world.
Neymar had already missed the 3-1 weekend win against Lille due to suspension.
Cristiano Ronaldo, who also won the FIFA Men's Player of the Year award in October, added the 2017 Ballon d'Or to his previous wins in 2008, 2013, 2014 and 2016.