Kevin De Bruyne set up three goals inside the first 32 minutes before capping a brilliant individual display by rounding off the scoring.
Manchester City's quest for four trophies continued with a 5-0 thrashing of Burnley in FA Cup.
The win over Everton, moved Manchester City two points ahead of Liverpool, who host Manchester United on Sunday.
Kevin De Bruyne limped off in the closing minutes of City's 2-0 victory at the Etihad Stadium.
Manchester City initially feared that De Bruyne would be out of action until late November.
Gareth Bale and Kevin De Bruyne were among the first 10 nominees for the Ballon d'Or award announced on Monday.
Kevin De Bruyne will not have to undergo surgery on the injury which he suffered in training on Wednesday.
Kevin de Bruyne is undergoing tests on his right knee after sustaining an injury at training.
Kevin de Bruyne scored eight goals and provided 16 assists in City's title win.
This is the third edition of the Best FIFA awards following the end of a six-year merger between the FIFA honour and France Football's Ballon d'Or in 2016.
World Cup 2018 Semi Final: Samuel Umtiti's header propelled France to tournament final for the first time in 12 years.
A 'golden generation' featuring Thibaut Courtois, Kevin De Bruyne, Eden Hazard and Romelu Lukaku helped Belgium edge past Brazil in the quarters.
FIFA World Cup 2018 Quarter Final, Brazil vs Belgium, from Kazan Arena: Brazil Knocked Out After 1-2 Loss To Belgium In Quarters
Eden Hazard and Kevin De Bruyne have come to Russia with a considerable weight of expectation on their shoulders.
Mohamed Salah matched a Premier League record tally for a single season by scoring his 31st league goal of the campaign in a 2-2 draw at West Brom.
Liverpool's Mohamed Salah, with 30 league goals this season, was also included.
Kevine De Bruyne has been one of the standout players in Manchester City's record-breaking campaign, but he knows Pep Guardiola was the mastermind behind their triumph.
Ederson's stopped Luka Milivojevic's late penalty to save Manchester City from defeat on Sunday but a 0-0 draw at Crystal Palace brought the Premier League leaders' record-breaking 18 match winning run to an end.
