In-form Serie A side Como, coached by Cesc Fabregas, is expected to provide a stern test to Antonio Conte's Napoli.
Gian Piero Gasperini's Atalanta have lost three of their opening five Serie A fixtures and were unlucky to only draw 0-0 with Arsenal in the Champions League on Thursday.
Como suffered multiple bankruptcies and tumbled down the pyramid after being relegated from Serie A little over two decades ago.
Spanish midfielder Cesc Fabregas, who won the World Cup in 2010, will play for Como in the Italian second division next season, Serie B announced on its official website on Monday
Monaco climb up to second in the table, four points behind PSG, but Lille can reclaim second spot and move to within two points of the leaders if they beat Lorient on Sunday.
Chelsea will only receive payments related to Cesc Fabregas' performance on the Mediterranean coast.
There was one 'giant-killing' on Saturday with third-tier Gillingham beating Premier League Cardiff 1-0.
Premier League: Chelsea, in fifth, are hard on Tottenham Hotspur's heels in the battle for a top four finish.
Sam Vokes scored twice as Burnley torpedoed defending champions Chelsea 3-2 at Stamford Bridge on Saturday in one of the most sensational opening-weekend results in English top flight history.
Argentine media called it the "wedding of the century" for Rosario, the gritty northern port city where Lionel Messi, 30, and his bride, 29, met when the player was nine years old.