Leipzig's 2-1 loss at Dortmund last week, their first in the league this season, has given Vincent Kompany's Bayern the chance to grow their lead at the top of the table.
Liverpool's return of 12 points means they are almost certainly already assured of a place in the knockout phase, but are closing in on sealing direct progression to the last 16 via a top-eight finish in the 36-team league.
Bayer Leverkusen coach Xabi Alonso said it was "too early" to write off his side's title defence despite dropping more points in Saturday's 2-2 draw at Werder Bremen.
Xabi Alonso's side now have 11 points from six matches, giving Bayern Munich the chance to extend their advantage at the top.
Bayern remain top of the Bundesliga table, two points ahead of RB Leipzig and three ahead of Leverkusen.
Bayer Leverkusen coach Xabi Alonso praised his side's German efficiency after the Bundesliga champions dispatched Dutch side Feyenoord 4-0 in Thursday's Champions League rout.
Bayern face Freiburg, who have won only once in 17 previous meetings.
Florian Wirtz scored in the 101st minute to seal a 3-2 victory for Leverkusen vs Gladbach.
Leverkusen have not lost a match in Germany in May 2023.
Xabi Alonso's side were thoroughly outclassed in a 3-0 loss to Atalanta in the Europa League final on Wednesday, their first defeat in any competition since May 2023 -- a run of 51 games.