Ferran Torres netted a first-half hat-trick to help Barcelona thrash Real Betis 5-3 and move four points clear at the top of La Liga on Saturday.
This was Barca's fifth consecutive Liga win after losing the Clasico against Real Madrid in October.
Barcelona made a triumphant return to their rebuilt Camp Nou stadium with a 4-0 win over Athletic Bilbao to go joint top of La Liga on Saturday, following two and a half years playing in exile.
Ferran Torres hit a hat-trick as Barcelona routed Valencia 5-0 on Thursday to cruise into the Copa del Rey semi-finals.
Lamine Yamal scored once and assisted twice as Barcelona sailed past La Liga opponents Real Betis in the Copa del Rey.
The comprehensive victory brings the Catalans to 37 points at the top of the league table, four ahead of second-placed Real Madrid, but with two extra matches played.
Barcelona continued their perfect start in the Champions League and warmed up for the Clasico at the weekend with a 2-1 win over Shakhtar Donetsk on Wednesday
Sergio Ramos has not played against Real Madrid since 2005 but on Saturday, his Sevilla team welcome the Spanish league leaders to the Sanchez-Pizjuan for a reunion.
Barcelona have been eliminated in the opening stage in the past two editions but this hard-fought triumph on the road puts them in a strong position as Group H leaders to avoid a third consecutive strike-out.
Pedri and Ferran Torres' late strikes earned La Liga champions Barcelona a 2-0 win over Cadiz in their first competitive home game away from Camp Nou on Sunday.