With a comfortable 2-0 cushion from the first leg, Bayern Munich is looking to finish off Marseille and advance to the Champions League semifinals.
The four-time champions have won 12 of their last 13 games at home in the competition, and have also won seven straight as they maintain their push for three trophies.
Bayern captain Philipp Lahm says "we're in a very, very good position. If we concentrate and play football, we won't run into trouble."
Marseille, meanwhile, has lost eight of its last nine games in all competitions.