The Arsenal manager Arsene Wenger confirmed that Fabregas would not be included in the squad for the Newcastle match while Nasri was "uncertain" to travel pending a fitness test.
"Cesc is not on strike. Cesc is not injured, he's not match fit. I don't want to go any deeper than that," Wenger said.
The Arsenal manager however, declined the reports that Cesc Fabregas and Samir Nasri were set to be sold on the eve of the Premier League campaign.
After days of intense speculation that Fabregas is on the brink of being sold to Barcelona, with Nasri heading to Manchester City, Wenger batted away questions about the two players at a press conference.
"I expect nobody to leave," Wenger said at the club's training ground as Arsenal prepared to travel to Newcastle for Saturday's season-opener.
"The best thing for us one day before the championship starts is not to focus on possible transfers.
"At the moment there is no news. If there is news I promise I will give it. I will decide what's best for the club."
Asked if he was disappointed at the attitude of Fabregas and Nasri in apparently engineering their transfers, Wenger replied: "My personal feelings are not important. What is important is the club and how well we do.
"I have not been disappointed with their attitudes. They are professionals. I take nothing personally.
"The transfer speculation is disruptive but that is not an excuse."
Several British reports on Thursday said Arsenal had agreed a transfer deal with Barcelona which would see Fabregas return to his boyhood club.
In an interview on Arsenal's official website late on Thursday, Wenger said he hoped the Fabregas situation would "be sorted out very quickly one way or the other."
He also said he hoped to resolve the uncertainty surrounding Nasri before the start of the new Premier League campaign season.
"Ideally you want it to be sorted out before the season starts," he said.