Top-ranked Serena Williams is seeded No. 1 as she seeks her third straight U.S. Open title. (Djokovic, Federer top two seeds in US Open)
The U.S. Tennis Association followed this week's WTA rankings in announcing the seedings on Wednesday.
French Open runner-up Simona Halep is seeded second after reaching a career-best ranking this month. She has never advanced past the fourth round at the U.S. Open.
Wimbledon champion Petra Kvitova is seeded No. 3 with third-ranked Li Na out because of a knee injury. Agnieszka Radwanska moves up to No. 4.
Five-time major champ Maria Sharapova is seeded fifth, meaning there's a chance she could face Williams in the quarterfinals. The runner-up the last two years, Victoria Azarenka, is seeded 16th after an injury-plagued season.
Venus Williams is seeded 19th.
The draw is Thursday, and the tournament starts Monday.