Top seeded American John Isner was sent crashing out of the ATP and WTA Memphis Open after losing to Austrian Jurgen Melzer 6-3, 7-6 (8/6) in a quarter-final match on Friday.
Isner, who hammered 48 aces in his first two matches in Memphis, fired 11 aces against Melzer in the 81 minute match at the $1.1 million indoor hardcourt tournament at The Racquet Club of Memphis.
Isner also had two double faults and won just 67 percent of his first-serve points.
Melzer won 80 percent of his first-serve points, had seven aces and saved both of his break point chances.
Third seeded Czech Radek Stepanek also cruised into the semis surviving a first-set tie break before dominating the second set to beat Sam Querrey 7-6 (7/5), 6-0.
Stepanek, who finished second here three years ago, posted four service breaks, compared to just one service break for the wild card and 2010 Memphis champ Querrey.
Taking the court later is fourth seed Milos Raonic of Canada who meets Belgian Olivier Rochus in another quarter-final match. Poland's Lukasz Kubot faces German Benjamin Becker.
Raonic lost to American veteran Andy Roddick in last year's Memphis final and is coming off his second win of 2012 in San Jose last week.
On the women's side of the draw, fourth seeded Marina Erakovic of New Zealand and Sweden's Sofia Arvidsson will meet in the final after winning their semi-final matches on Friday.
Erakovic outlasted Russia's Vera Dushevina 6-1, 4-6, 6-4 and Arvidsson eased past Alberta Brianti, of Italy, 6-3, 7-5.