Aslan Karatsev powered 50 winners, including nine aces, past the shell-shocked Diego Schwartzman who could muster only five of his own in return in a 1hr 52min drubbing.
Alexander Zverev beat Diego Schwartzman 6-3, 4-6, 6-3 on Wednesday to keep alive his hopes of another ATP Finals triumph in London.
Novak Djokovic is playing in the ATP Finals in London at the end of a coronavirus-truncated season but the new campaign is due to start in just seven weeks' time.
Novak Djokovic defeated Diego Schwartzman 6-3, 6-2 at the ATP Finals in London.
Rafael Nadal beat Australian Jordan Thompson 6-1, 7-6 (7/3) to set up a quarter-final match against Pablo Carreno Busta.
French Open 2020: Rafael Nadal will face either Novak Djokovic or Stefanos Tsitsipas in the final of Roland Garros.
French Open: Novak Djokovic will be up against Stefanos Tsitsipas while Rafael Nadal takes on Diego Schwartzman in the semi-finals.
Dominic Thiem knocked out of French Open after losing 6-7, 7-5, 7-6, 6-7, 2-6 to Argentna's Daniel Schwartzman in the quarter-finals.
Dominic Thiem survived a massive scare to reach the French Open quarters, but despite being stretched to his limit, the World No.3 still had time to showcase his mindblowing football skills.
Rafael Nadal was making his comeback after a six-month coronavirus-enforced break having skipped the US Open ahead of Roland Garros with its first round on September 27.
Virtual Madrid Open: Andy Murray downed Belgium's David Goffin in the final but the drama of the online tournament took place in the previous round.
Novak Djokovic beat Diego Schwartzman 6-3, 6-4, 6-4 on Rod Laver Arena to book a quarter-final clash with big-serving Milos Raonic.
Nadal was taken to four tough sets in almost four hours before winning 6-3, 6-7 (4/7), 6-3, 6-3.
Nick Kyrgios defeated Argentina's Diego Schwartzman 6-0, 6-2, 7-6 (8/6) to storm into the second round at Wimbledon.
Roger Federer, looking to win his 85th career title ahead of the French Open, looked rattled all afternoon. Losing the first set, he eventually prevailed 2-6, 6-2, 7-5, after almost two hours on court.
Ferrer also won his first-round match on Tuesday, defeating Antonio Veic 6-0, 6-3. Ferrer is the three-time defending champion and won last week in Buenos Aires, his second title of the season.