Rafael Nadal was in virtuoso form to charge past the 27th seed 6-1, 6-2, 6-4 and make the round of 16 at Melbourne Park for a 13th time.
Novak Djokovic was never in danger in his 6-3, 6-4 triumph over 53rd-ranked Spaniard Pablo Carreno Busta.
The 2014 US Open champion Marin Cilic needed just an hour and five minutes to clinch his third win over the 11th-ranked Spaniard.
Pablo Carreno Busta beat Argentine 29th seed Diego Schartzman 6-4, 6-4, 6-2.
The field of newbies, who compete on Sunday for the first four spots in the US Open quarterfinals, is as eclectic as they come.
Fourth seeds Jamie Murray and Bruno Soares eased to a 6-2, 6-3 win over unseeded Spaniards Pablo Carreno Busta and Guillermo Garcia-Lopez in the US Open men's doubles final
Dominic Thiem blasted 47 winners, 20 in the last set, on his way to a 1-6, 6-4, 6-4, 7-5 victory over Pablo Carreno Busta. In women's singles, fifth-seed Simona Halep defeated Timea Babos 6-1, 2-6, 6-4 to advance to Round 4 of 2016 US Open
Eight-time French Open champion Rafael Nadal said in an interview published on Tuesday that he is not setting his sights on Roger Federer's record of 17 Grand Slam titles, despite claiming his 12th at Roland Garros last weekend.
Rafael Nadal smiled back from the front pages of Spanish newspapers on Monday, after he lifted his record eighth French Open title with a 6-3, 6-2, 6-3 win over compatriot David Ferrer.
Rafael Nadal's stirring comeback from a career-threatening knee injury was crowned at the French Open on Sunday when he won the Roland Garros title for a record eighth time to move into joint third place in the all-time list of Grand Slam winners on 12.
Rain and unseasonally cold temperatures in the French capital were the last thing the 31-year-old Spaniard wanted to see for his first Grand Slam final in what was his 42nd attempt.
Rafael Nadal may have had a huge advantage over very good friend and compatriot David Ferrer up till now but the Spaniard will know that his fellow country-man has all the ingredients and qualities to overcome all that and clinch the 2013 French Open men's singles title.
He has won 58 out of 59 matches at Roland Garros and boasts a 19-4 winning record over Ferrer. Sixteen of those wins have been on clay. The 31-year-old Ferrer has won just one of their claycourt encounters and that was their first career meeting in 2004 when Nadal was just 16.
Nadal will take a 19-4 career record over Ferrer into the final with 16 of those wins coming on clay. Ferrer's only win over Nadal on the surface was back in 2004 at Stuttgart, the pair's first meeting when the seven-time French Open champion was just 16.
The Bryans still remember from a decade ago when they could afford to stay in Paris in what was practically only a hole in a wall. When they won the Australian Open this year, they broke a tie for most doubles majors with Australian greats John Newcombe and Tony Roche.
Twelve months ago, Williams suffered her worst defeat at a Grand Slam when she was knocked out of the first round in Paris. But, one year on, the 31-year-old has become the oldest women's champion at the French Open in the Open era, having also captured the Wimbledon and US Open crowns.
Her French coach Patrick Mouratoglou described her efforts as those of an "immense champion" and that last year's shattering loss had created a new-look Serena Williams.
Sharapova started the match a clear underdog against a player who had run up a career-best 30 match win streak and who had been playing some of the finest tennis seen in the women's game in years.