Tsitsipas burst onto the scene by reaching his first tour-level final at Barcelona last April.
Roberto Bautista Agut will face Stefanos Tsitsipas for a place in the semifinals.
Andy Murray fought to the very end before losing his Australian Open first-round match 6-4, 6-4, 6-7 (5/7), 6-7 (4/7), 6-2 to Roberto Bautista Agut.
Gutsy Andy Murray lost an epic Australian Open farewell match 6-4, 6-4, 6-7 (5/7), 6-7 (4/7).
Roberto Bautista Agut defeated Novak Djokovic for the second time in his career.
The Serbian has reached the second week at Roland Garros for the last nine years in a row.
Roger Federer outclassed Roberto Bautista Agut in straight sets to inch closer to his sixth title of the season.
Roberto Bautista Agut lost only eight points on his serve while in contrast Danill Medvedev's serve was always under pressure in the Chennai Open final, which lasted an hour and 11 minutes
Women's singles second seed Agnieszka Radwanska and sixth seed Simona Halep lost their Round of 16 matches on a rain-hit day at the French Open.
Novak Djokovic lost the first set to Roberto Bautista Agut in the men's singles pre-quarterfinals before rain halted play at French Open again.
Rafael Nadal is looking for his first title on any surface since last summer and will meet 57th-ranked Aljaz Bedene. On the other hand, Roger Federer will play his first match in more than two months.
It was Tomas Berdych's fourth win in six meetings with Roberto Bautista Agut, who upset former US Open champion and 12th seed Marin Cilic to reach the round of 16.
Roberto Bautista Agut won the ATP Auckland Classic Title after Jack Sock was forced to withdraw early from the final due to flu.
The Punjab Marshalls clinched the tie 23-15 after it went into 'overtime', in which Marcos Baghdatis won the last game to seal the deal at the CLTA Stadium.
Roberto Bautista Agut featured in three matches -- men's singles, men's doubles and mixed doubles -- and his side won all those games.
Defending champion Marin Cilic beat Roberto Bautista Agut in straight sets in a repeat of last year's final.
Second seed Roger Federer goes on to face enigmatic French star Gael Monfils for a place in the semi-finals.