The Indo-Czech pair lost 3-6 3-6 to Andy Murray and Colin Fleming in the second round. Earlier, Rohan Bopann and Sania Mirza lost their respective matches
The third seeds edged British pair Colin Fleming and Jonathan Marray 7-6 (7/5), 4-6, 10-4 in an hour and 32 minutes.
It was eighth ATP doubles title for Bopanna, who has been ignored for India's Davis Cup tie against Indonesia.
The Indo-British pair beat third-seeded duo of Julian Knowle of Austria and Filip Polasak of Slovakia 7-5 6-1 in the semi-finals.
India's singles challenge had ended with the defeat of Somdev Devvarman, who went down fighting against Australia's Bernard Tomic in the second round.
Somdev, who had shocked world number 39 Benoit Paire in the opening round, went down 3-6 5-7 against Bernard Tomic in the second round in one hour and 12 minutes.
The Indo-Pak express of Rohan Bopanna and Aisam-Ul-Haq Qureshi advanced to the quarterfinals of the ATP Paris Masters with a 6-4, 6-3 win over Britain's Colin Fleming and Jamie Murray.
Robin Soderling of Sweden beat Marin Cilic of Croatia 6-7 (8), 6-3, 6-3 Sunday in the final of the Open 13 to earn his ninth career title.