The 37-year-old Swiss master made light of his assignment on Rod Laver Arena, wrapping up the match 6-3, 6-4, 6-4.
Rafael Nadal needed all his trademark grit against Alexander Zverev, 19, dubbed "the future of tennis", and his superior fitness told as he ground out a thrilling 4-6, 6-3, 6-7 (5/7), 6-3, 6-2 win
Denis Istomin defeated World No.2 and defending champion Novak Djokovic in five sets at the Australian Open on Thursday.
Denis Istomin scored the biggest win of his career on Thursday when he defeated defending champion Novak Djokovic in the second round of Australian Open.
Novak Djokovic was the defending men's singles champion of the 2017 Australian Open.
Denis Istomin, top seed, defeated defending champion Lucas Lacko of Slovakia in the final of the $125,000 tournament.
Denis Istomin prevailed 7-6 (7/1), 7-6 (8/6) to beat Sam Querrey, ranked 48 places above him, having lost four of his last five matches against the American.
Stanislas Wawrinka defeated Denis Istomin 6-3, 6-3, 6-4 in a show of strength to move into the fourth round of Wimbledon 2014.
Third seed Murray overcame dropping a set for the second time in the tournament to set up a clash against Stanislas Wawrinka.
Klaudiya Istomin played a crucial role in her son's development after a 2001 car crash hospitalized him for three months and kept him off the court for two years.
Hewitt, rested from Friday's opening singles, partnered Matthew Ebden to battle out a 7-5, 6-7 (4/7), 6-4, 3-6, 6-3 win over the Uzbek pairing of Denis Istomin and Farrukh Dustov.
Isner struggled through a number of unforced errors and at least a handful of double faults against Istomin - ranked 63rd.
Denis Istomin capitalized on all five break point chances as he advanced to the ATP Tour's SAP Open quarter-finals with a 6-3, 6-7 (5/7), 6-2 win over Benjamin Becker on Thursday.
Anderson, 26, is coming off a successful week at the mixed teams Hopman Cup in Perth for South Africa, where he beat Fernando Verdasco and John Isner.
Murray, back on court after playing the late match on Thursday night, took his chances against Istomin on a few key points, edging out the world number 43 in two tight sets in just over an hour and a half.
It was a mixed day for Indian tennis as Sania Mirza of India and Nuria Llagostera of Spain moved into the women's doubles final of $4.8 million China Open tennis championship while Mahesh Bhupathi and Rohan Bopanna were knocked out in the quarter-final.
Denis Istomin became the first player from Uzbekistan to reach the fourth round of a Grand Slam tournament on Friday, beating Alejandro Falla of Colombia 6-3, 6-4, 3-6, 7-6 (5) at Wimbledon.
India's nightmare at the French Open continued with Leander Paes and his Austrian partner Alexander Peya being dumped out of the men's doubles second round by Mikhail Elgin of Russia and Denis Istomin of Uzbekistan here Saturday.