Williams returned from giving birth to her first child to reach the 2018 Wimbledon and US Open finals, but suffered upset losses in both to leave her stuck on 23 major wins.
Andy Murray was not included when the China Open draw was made on Saturday.
Andy Murray had this week produced some of his best tennis of the year at the Shenzhen Longgang Sports Centre.
Andy Murray now has a 6-0 head-to-head record against David Goffin.
Andy Murray reached the pinnacle of the sport in 2016 and has three Grand Slam singles titles on his shelf.
Andy Murray has played just five tournaments this season and is currently ranked No. 308.
Former Wimbledon champion Andy Murray will play two tournaments in China before bringing an end to his troubled campaign.
Andy Murray has played in only one Grand Slam since last year's Wimbledon as he struggles to return to peak form following his long injury lay-off.
Andy Murray lost 5-7, 6-2, 4-6, 4-6 to Spain's Fernando Verdasco in US Open second round.
Serena Williams re-established her customary superiority, hammering Daria Gavrilova 6-1, 6-2 to reach the second round of the Cincinnati Masters on Monday.
Two-time Cincinnati champion Serena lost the Wimbledon final to Angelique Kerber last month.
Alexander Zverev will face 10th-seeded Greek 19-year-old Stefanos Tsitsipas in the ATP Washington Open semis.
Andy Murray, three-time Grand Slam champion, outlasted Romania's 93rd-ranked Marius Copil 6-7 (5/7), 6-3, 7-6 (7/4).
Andy Murray needed seven match points to subdue the 80th-ranked Mackenzie McDonald 3-6, 6-4, 7-5.
Murray, the 2013 and 2016 Wimbledon winner, had only just returned to action after 11 months on the sidelines due to a hip injury that needed surgery in January.
Andy Murray was due to play France's Benoit Paire in the first round on Tuesday.
Andy Murray is scheduled to play in his first round tie against France's Benoit Paire on Tuesday. But the former world number one, who was crowned Wimbledon champion in 2013 and 2016, is making slow progress in his return from hip surgery in January.
Roger Federer's 37th birthday may be fast approaching but the evergreen Swiss will be looking to clinch his ninth Wimbledon and 21st Grand Slam Title.