Iga Swiatek made light work of Emma Raducanu, beating her 6-1, 6-0 to progress to the Round of 16.
Teenage qualifier Learner Tien stunned last year's Australian Open runner-up Daniil Medvedev after Jannik Sinner roared back to take his place in the third round.
World No. 2 Iga Swiatek will face a tricky third round tie against Britain's Emma Raducanu.
Jannik Sinner and Iga Swiatek have both faced doping investigations.
World No. 1 Aryna Sabalenka will be aiming for a third straight Australian Open title.
Poland lost in the final for the second year in a row, having lost to Germany in 2024.
Coco Gauff and Iga Swiatek will battle for United Cup glory after the USA and Poland won their respective semi-finals on Saturday in Sydney amid bizarre circumstances.
Stefanos Tsitsipas of Greece was stunned by 78th-ranked Alexander Shevchenko.
Novak Djokovic is confident he can still win Grand Slams, starting at the Australian Open, with the Serbian kickstarting his bid for an unprecedented 11th titleand record 25th major crown in Brisbane.
Last spring, the sports watchdog was severely criticized for clearing swimmers who tested positive for trimetazidine to compete at the Tokyo Olympics in 2021.