The 20-year-old Pole, who won the title at Roland Garros in 2020, is over 2,000 points ahead of defending French Open champion Barbora Krejcikova in the new WTA rankings.
Iga Swiatek swept to victory at the Italian Open on Sunday, beating Ons Jabeur 6-2, 6-2 to retain the title and claim her fifth tournament crown in a row.
Stefanos Tsitsipas moved into the Italian Open final on Saturday after beating Alexander Zverev 4-6, 6-3, 6-3 in an entertaining last four battle in Rome
Italian Open: Novak Djokovic defeated Stan Wawrinka with a 6-2, 6-2 win to enter the quarter-finals.
Iga Swiatek, who won the French Open in 2020, is set to become the new WTA world number one, on Monday.
Naomi Osaka will face American Danielle Collins for a place in the semi-finals of the Miami Open after the Japanese star beat Alison Riske while newly minted world number one Iga Swiatek also advanced comfortably.
Iga Swiatek will move into the top spot vacated by Australian Ashleigh Barty after the three-time Grand Slam champion announced her retirement earlier this week.
Poland's Iga Swiatek is poised to become the new world number one after Ashleigh Barty said that she will remove herself from the WTA rankings.
Alexander Zverev was stunned in his opening match 6-2, 4-6, 7-6 (7/2) by 39th-ranked American Tommy Paul.
"No pain, no gain" is a mantra often heard anywhere elite athletes train and Danielle Collins has had more than her fair share of pain on the long road to a first Grand Slam final.