Former No. 1s Ana Ivanovic and Jelena Jankovic were knocked out of the China Open third round in straight sets on Wednesday.
Meanwhile, the second round was completed when Maria Sharapova downed Sorana Cirstea of Romania 6-2, 6-2, and Slovenian qualifier Polana Hercog came from 5-1 down in the third set to beat Russia's Ekaterina Makarova 7-6 (5), 3-6, 7-6 (3).
Ivanovic was ousted 6-4, 6-3 by Romina Oprandi of Switzerland, who replaced an ill Serena Williams in the draw.
Jankovic fell apart from leading 5-2, going out to Carla Suarez Navarro of Spain 7-5, 6-4.
Among the men, Austria's Jurgen Melzer defeated Ukraine's Alexandr Dolgopolov of Ukraine 7-6 (9), 2-6, 6-1.