Manchester City's quest for four trophies continued with a 5-0 thrashing of Burnley in FA Cup.
Jeffrey Schlupp, Andros Townsend and Luka Milivojevic were the goal scorers for Crystal Palace.
Apart from Pierre-Emerick Aubameyang, substitute Alex Iwobi scored the third goal for Arsenal while Ashley Barnes scored the lone goal for Burnley.
Christian Eriksen scored a stoppage-time winner for Tottenham Hotspur against Burnley in the Premier League.
Raheem Sterling inspired Manchester City to a 3-1 win over Bournemouth, while Crystal Palace clinched a crucial 2-0 victory over Burnley.
Matt Ritchie's embarrassing effort will be one of the top contenders of Premier League's miss of the season award.
Victory saw Newcastle move up into 13th place in the Premier League table, four points clear of the bottom three.
Eden Hazard was ruled out by a back problem sustained in a 2-2 draw with Manchester United last weekend.
Hart played a major role in England reaching the World Cup finals keeping seven clean sheets in the nine qualifiers.
Manchester City took the lead in the 17th minute with Aguero continuing his remarkable run of goalscoring form at the Etihad.
Lukaku's first-half double was enough for a well-earned three points as United bounced back from consecutive defeats to Brighton and Tottenham.
The 31-year-old, who failed to make the England squad for the World Cup, has signed a two-year contract.
West Ham United captain Mark Noble pinned one fan down to the ground and his team-mate James Collins asked the remaining two fans to leave.
The Clarets thought they had rescued a point when they equalised on the 87th minute, but Ragnar Klavan met Dejan Lovren's header in the final moments.
Manchester United came from two goals down to rescue a dramatic 2-2 draw against Burnley thanks to Jesse Lingard's double.
Harry Kane took his goal tally in the Premier League to 36 for the calendar year, equalling the record set by Alan Shearer with Blackburn Rovers in 1995.
Tiemoue Bakayoko opened the scoring midway through the first half with a deft clipped finish, offering an answer to supporters who have criticised him for a series of poor performances following his July move from Monaco.