Arsenal had been almost flawless in 2024, with 16 wins and one draw, away to City, in their 18 league matches.
Manchester City became the first team to win four Premier League titles in a row after beating West Ham United 3-1 at the Etihad Stadium on Sunday.
Premier League Final Day Live Streaming: The Premier League title will be decided on the final day of the season with both Manchester City and Arsenal still in the race.
Elijah Adebayo kept Luton in the hunt to avoid relegation from the Premier League as his equaliser rescued a 1-1 draw against Everton on Friday.
Everton secured their first win in a Merseyside derby at Goodison Park since 2010 to leave Liverpool's Premier League title aspirations in ruins after a 2-0 defeat on Wednesday.
Cole Palmer scored four goals to put Chelsea within touching distance of the Premier League's top six after a 6-0 win over Everton on Monday.
The Premier League said on Monday a speeded-up, "expedited" process will be put in place after Everton appealed against a two-point penalty imposed on the club for breaching financial regulations.
Tottenham missed the chance to move into the Premier League's top four after a 1-1 draw at West Ham, while Newcastle were also held 1-1 by Everton on Tuesday.
Premier League strugglers Everton revealed an 89.1 million pounds ($112 million) loss for the 2022-23 season in their latest financial accounts on Sunday.
Manchester United kept alive their faint hopes of finishing in the Premier League's top four with a 2-0 win against Everton, while Arsenal prepared for their chance to seize top spot later on Saturday.
Premier League strugglers Everton salvaged a 2-2 draw with Tottenham thanks to Jarrad Branthwaite's last-gasp equaliser, while Aston Villa moved into fourth place with a 5-0 demolition of Sheffield United on Saturday
Forest survived a scare to beat third-tier Blackpool 3-2 after extra-time, while Everton were 1-0 winners against Crystal Palace in another of the night's third-round replays.
With Everton and Nottingham Forest currently embroiled in a relegation battle, that would plunge their top-flight status into severe doubt.
Manchester City came from behind to beat Everton 3-1 on their return from the Club World Cup on Wednesday.
Chelsea manager Mauricio Pochettino said his side needs strengthening in the transfer market after a 2-0 defeat at Everton on Sunday
Newcastle were made to pay for two uncharacteristic errors by England international Kieran Trippier as fatigue hit the injury-ravaged Magpies in the closing stages.
Everton face a 12-point deduction after an investigation into alleged breaches of financial rules by the Premier League club
Arsenal finally ended their six-year wait for a Premier League victory at Everton as Leandro Trossard fired the title-chasing Gunners to a 1-0 success.