Spanish holders Sevilla and English side Everton have been handed tricky ties in the draw for the UEFA Europa League groups stage made in Monaco on Friday.
Sevilla, bidding for a record fourth title in the second-tier European competition, won last season by beating Benfica on penalties.
But in their path are Standard Liege of Belgium and Dutch two-timer winners Feyenoord, in a Group G which also includes Croatian minnows Rijeka.
English side Everton have been drawn in Group H alongside Wolfsburg of Germany, French side Lille and Turkish outfit Krasnodar, who advanced past Real Sociedad in the preliminary rounds.
However with Samuel Eto'o and Romelu Lukaku in their strike force, Everton seem well armed up front.
Wolfsburg also have several top-class players such as Ivica Olic, Josuha Guilavogui, Kevin De Bruyne and Brazilian Luiz Gustavo.
Eliminated by Porto in the Champions League, Lille can count on their tight defence which helped them to third in Ligue 1 last season.
In Group C, English side Tottenham are favourites but face three tough trips to Besiktas in Turkey, Serbian side Partizan Belgrade and Greek outfit Asteras Tripolis.
Scottish champions Celtic avoided meeting Legia Warsaw, the side who they controversially beat in Champions League qualifying due to a technicality, and are in Group D alongside Salzburg, Dinamo Zagreb and Astra Giurgiu.
Celtic manager Ronny Deila told UEFA.com: "It's an interesting group. There are good teams but we are going to fight to go through. We are disappointed we didn't make the Champions League but we have to close this chapter for this year and remember the feeling we had.
"We have to work really hard, learn from our defeats and use that experience when we hopefully get in that situation again next year."
In Group A the battles should be between Villarreal and Moenchengladbach, while Group E is all to play for between PSV Eindhoven, Panathinaikos, Dynamo Moscow and outsider Estoril Praia.
The four Italian clubs all drew groups which they are capable of advancing through, even if Inter Milan must be wary of Dnipropetrovsk and Saint-Etienne in their Group F which also includes first-timers Qarabag of Azerbaijan.
Napoli should have an easier time against Sparta Prague, Swiss side Young Boys and Bratislava in Group I, as should Fiorentina, who are up against Greek side PAOK in Group K, which also includes Guingamp of France and Belarussian side Dynamo Minsk. Torino play Copenhagen, Club Brugge and Helsinki in Group B.
The six matches will take place on September 18, October 2 and 23, November 6 and 27 and December 11.
The top two from each group will qualify for the last-32 where they will be joined by the third-placed finisher from the Champions League group stages.
The final takes place in Warsaw on May 27 with this season's winners qualifying for next year's Champions League for the first time.