Toffees left-back Digne was sent off for a dangerous challenge on Kyle Walker-Peters in the second half, despite his claims he tripped when he stood on the Southampton defender's heel.
The Netherlands international suffered cruciate ligament damage after a tackle from Everton goalkeeper Jordan Pickford in last week's Merseyside derby and is awaiting a date for surgery.
Virgil Van Dijk hobbled off after a shocking challenge from Everton goalkeeper Jordan Pickford in a 2-2 draw in the Merseyside derby on Saturday.
A video has spread on social media in which onlookers can be heard shouting "Jordan" as a fight breaks out before the man, believed to be Pickford, is dragged away.
Divock Origi, making his first Premier League appearance since August 2017, scored the decisive 96th-minute goal for Liverpool vs Everton.
Pickford wants to go onto become a "legend" at Goodison Park.
World Cup 2018 Semi-Final, Croatia vs England: Croatia thump England in extra-time to reach their first-ever final.
Goalkeeper Jordan Pickford earned rave reviews following his heroics in England's win over Colombia.