Spurs already had an outbreak that affected nine first-team players in December and saw three games called off.
Premier League: Tottenham Hotspur's game at Brighton on Sunday has been postponed due to a severe coronavirus outbreak at the north London club.
Premier League: Manchester United started the Ralf Rangnick era with a 1-0 win against Crystal Palace on Sunday as Tottenham crushed Norwich 3-0 to extend their recent revival under Antonio Conte.
Premier League: Gareth Bale struck twice as Tottenham registered a 4-0 win over Burnley on Sunday.
West Ham United climbed two points above Chelsea into the Champions League spots as their unexpected European challenge gathered pace with a seventh win in their last nine league matches.
Teenager Curtis Jones sealed a 1-0 win for Liverpool against Everton while Chelsea thrashed Nottingham Forest 2-0 in the FA Cup.
Tottenham Hotspur suffered an embarrassing League Cup third-round defeat on penalties at fourth-tier Colchester.
Manchester City were denied a win when Gabriel Jesus saw a stoppage-time winner disallowed on review for a handball by Aymeric Laporte.
Lucas Moura was left on the bench for the final in spite of scoring a dramatic hat-trick in Tottenham Hotspur's stunning semi-final comeback at Ajax.
Tottenham only had to match Inter Milan's result at home to PSV Eindhoven, which they did, as the Italians only managed a 1-1 draw themselves.