Chelsea made it four wins from four matches in Group L by edging out a spirited BATE Borisov 1-0 in Belarus.
England were denied a point when referee Danny Makkelie awarded a foul in favour of Spanish goalkeeper David de Gea for minimal contact with Danny Welbeck.
Arsenal registered a 5-1 aggregate win over AC Milan in the Europa League last 16 to reach their first European quarter-final since 2010.
Danny Welbeck, 25, has made 35 appearances for England and scored 14 international goals
Danny Welbeck and Alex Iwobi netted a goal each as Arsenal F.C. defeated Everton F.C. 2-0.
Arsenal's loss to Watford on Sunday was their first defeat in the FA Cup since a 1-0 fifth-round defeat by Blackburn Rovers in February 2013.
Marcus Rashford marked his Premier League debut for Manchester United by scoring in the 29th and 32nd minutes, three days after a double in the Europa League against FC Midtjylland.
Fielding a weakened team, Arsenal created a slew of chances but were denied by a mixture of poor finishing and good goalkeeping from Eldin Jakupovic.
Danny Welbeck's goal, after fellow substitute Theo Walcott had cancelled out Jamie Vardy's first-half penalty, saw Arsene Wenger's men complete a league double over Leicester following their 5-2 win in September.
Danny Welbeck has not played since April due to a knee injury, while Daniel Sturridge have only 15 Liverpool starts since the beginning of last season, due to various injuries.
Danny Welbeck, signed by Arsenal from Manchester United on deadline day in September 2014, last played in April, missing both the FA Cup final and end-of-season internationals.
Danny Welbeck sustained a knee injury in Friday's 4-0 win over Lithuania in a Euro 2016 qualifier.
Born in Manchester, Danny Welbeck joined United at the age of eight but was allowed to sign for Arsenal last September after new manager Louis van Gaal decided he was surplus to requirements.
A Manchester-born United academy graduate, England striker Welbeck left for Arsenal in a
Danny Welbeck returned to haunt his former club as Arsenal claimed a first victory at Old Trafford since September 2006.
Arsenal F.C., who will host Southampton on Wednesday, are sixth in the points table, two points behind Manchester United in fourth.
Danny Welbeck won it for Arsenal on the hour when he met Santi Cazorla's cross with a powerful close-range header that Ben Foster could only help into the net.
Danny Welbeck has impressed for the Gunners since his 16 million pounds ($25.1 million, 20 million euros) transfer deadline day switch from United.