Jan Vertonghen, whose contract was extended in June until the end of the current season, made more than 300 appearances for Spurs after joining the club from Ajax in 2012.
Jan Vertonghen's family was held at knifepoint at their London home during a burglary when the Belgium star was away on Champions League duty with Tottenham Hotspur.
Jan Vertonghen's stoppage time header continued Tottenham's turnaround under Jose Mourinho as Spurs moved up to fifth with a 2-1 win at Wolves.
World Cup 2018 Semi Final: Samuel Umtiti's header propelled France to tournament final for the first time in 12 years.
Jan Vertonghen reportedly damaged ankle ligaments in training and is set to be sidelined for up to four months