Right-back Jerome Boateng and defensive midfielder Sami Khedira are both nursing knocks ahead of Germany's final World Cup group match against the USA on Thursday, according to the German FA.
Boateng suffered a strain in his left thigh and failed to come out for the second-half of Germany's 2-2 draw with Ghana on Saturday in Group G.
Khedira strained a ligament in his left knee in the draw and the pair were both treated at Germany's World Cup base on Sunday and missed training.
Germany team manager Oliver Bierhoff said Khedira should be fit to face former German national team boss Jurgen Klinsmann's Stars and Stripes in Recife and it is hoped the pair will be able to train on Monday.
Thomas Mueller, who scored a hat-trick in their opening 4-0 win against Portugal, will be fit despite needing stitches in a head wound after crashing into the shoulder of Ghana defender John Boye in the final stages.