Liam Livingstone replaced Joe Denly who was ruled out of the remaining two games due to back spasm.
West Indies will be looking to take an unassailable 2-0 series lead at Old Trafford while England will hope Joe Root's return can inspire them to victory.
There looks certain to be change up the order with Joe Denly's knocks of 18 and 29 doing little to show that he can haul his performances up to the required standard for a long-term Test number three.
With England and the West Indies boasting of proven pace attacks, the series could boil down to which side fares better in the batting department.
Desperate times call for desperate measures, as former England cricketer Robert Key found out after getting a haircut from his wife.
Ben Stokes was unbeaten at 67 at stumps, while Joe Denly scored 71 and Rory Burns made 52 as England edged New Zealand on Day 1.
Jason Roy has failed to impress as an opener and the experiment with him has ended as Joe Denly said he had been asked to open the innings.
Joe Root set to replace Joe Denly at number three spot in the first Ashes Test match at Edgbaston on Thursday.
Jofra Archer's late bid for a World Cup place was rewarded with the Barbados-born fast bowler being named in hosts England's 15-man squad for the tournament.
England have named Joe Denly in their World Cup 2019 squad.
Jason Roy hit 69 off 36 balls and Joe Denly took four wickets as England beat Sri Lanka by 30 runs in the one-off T20I.
Joe Denly is to miss the first ODI against Australia at the Oval on Friday after sustaining a left knee injury during practice on Thursday.