After being outplayed in the first set, Sania Mirza-Ivan Dodig mounted an early fightback in the second. However, Spears and Cabal held off the challenge from the Indo-Croatian pair to carve out a memorable win.
Sania Mirza and Bruno Soares defeated American Abigail Spears and Mexico's Santiago Gonazalez 6-1, 2-6, 11-9 to win the US Open mixed doubles title on Friday.
Sania Mirza has won three Grand Slam titles, all in the mixed doubles category. She won the 2009 Australian Open, 2012 French Open and 2014 US Open.
Indo-Spanish pair of Sania Mirza and Nuria Llagostera lost out to Americans Raquel Kops-Jones and Abigail Spears in the women's doubles quarter-finals of the Kremlin Cup here on Thursday.
A couple of hours after reaching her seventh Wimbledon final, Serena Williams returned to Centre Court with sister Venus to secure a spot in the semifinals of the doubles tournament.