The tournament will be played March 7-20 in Indian Wells features both the ATP and WTA tours.
Blake, a finalist in 2006, battled injuries throughout last year, but has regained his health. Raonic advanced through qualifying to make the main draw at the Australian Open in January and reached the fourth round. He won his first ATP title recently in San Jose and then made the finals in Memphis the following week.
Kei Nishikori of Japan, American Ryan Harrison, and Australian Bernard Tomic were the other men to receive wild cards.
Vandeweghe, who played on the U.S. Fed Cup team in November, along with fellow Americans Christian McHale, Lauren Davis and Sloane Stephens received wild cards on the women's side. Also earning wild cards were Americans Vania King and Jill Craybas, and Sania Mirza of India.
Mark Philippoussis of Australia, the 1999 champion, received a wild card into the men's qualifying as he attempts a comeback.
Blake, Vandeweghe receive Indian Wells wild cards
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