Jodie Meeks scored a career-high 31 points and Jrue Holiday had 19 to lead Philadelphia over Cleveland.
Evan Turner scored 12 points for the Sixers, who moved a half-game ahead of Boston and back into sole possession of first place in the Atlantic Division. The Sixers have held the top spot in the Atlantic for all but a few days early in the season.
The Sixers romped without Andre Iguodala, who missed his second straight game because of left patella tendinitis. Meeks started in his place and was 7 of 10 from 3-point range.
Anthony Parker scored 14 points and Kyrie Irving had 12 for the Cavaliers.