Shane Lowry's 16-under overall total of 197 is the lowest after 54 holes in British Open history.
Italy's Francesco Molinari became the first European and only the fourth player ever to go 5-for-5 in a Ryder Cup.
After a 4 and 3 win over Tiger Woods and Patrick Reed in the morning fourballs, Tommy Fleetwood and Francesco Molinari thumped the 14-time major champion and Bryson DeChambeau 5 and 4 in the foursomes.
Tommy Fleetwood is dreaming of becoming the first English golfer to lift the Claret Jug since Nick Faldo in 1992.
Tiger Woods birdied on holes 3, 8, 10, 13, 14 but lost the advantage with bogeys on the par-five 9 and 15.