Flick also selected uncapped duo Werder Bremen striker Niklas Fuellkrug and 17-year-old Dortmund forward Youssoufa Moukoko.
Borussia Dortmund captain Marco Reus is set to return for Sunday's clash with league leaders Union Berlin, Dortmund coach Edin Terzic confirmed on Friday
Bundesliga: With the prolific Erling Haaland fit and firing again, Borussia Dortmund hope to round out the year in style and close the gap on league leaders Bayern Munich.
Borussia Dortmund vs Manchester City, Champions League: Phil Foden's 90th minute strike helped Manchester City edge past Borussia Dortmund 2-1 in the first-leg at the Etihad Stadium last week.
Borussia Dortmund twice came from behind to beat defending champions Bayern Munich 3-2.
France were held to a 0-0 draw by Germany in Munich in a flat start to the new UEFA Nations League.
FIFA World Cup 2018, Highlights Germany vs Mexico: Mexico beat defending champions Germany 1-0.
A groin injury means Marco Reus joins Julian Brandt, Sebastian Rudy and Karim Bellarabi to be excluded from the Germany squad while injured captain Bastian Schweinsteiger, who tore knee ligaments in March, was included.
German winger Marco Reus landed into fresh trouble with the police for yet another motoring offence. Reus was hit with a 540,000 euros (US$576,371) fine when it emerged that he had driven since 2011 without a valid licence.
Marco Reus has yet to win a major title in his career and missed out on the 2014 World Cup with Germany due to an ankle injury he suffered in the final warm-up match before flying to Brazil.