Gonzalo Montiel, who scored the winning penalty in the 2022 World Cup final, netted the decisive spot-kick after Gianluca Mancini and Roger Ibanez had failed to convert for Roma.
Jesus Navas has not been called up for national duty for 18 months now, despite his participation in 34 matches for Spain.
Manchester City defender Pablo Zabaleta has warned Viktoria Plzen there will be no let-up from his free-scoring team in Wednesday's Champions League clash at Eastlands.
Manchester City manager Manuel Pellegrini admitted he cannot explain the disparity between his side's home and away form after their 6-0 demolition of Premier League rivals Tottenham Hotspur.
On this occasion, Vicente del Bosque's side twice trailed before coming back to draw, with Eduardo Vargas netting Chile's two goals and Roberto Soldado and Navas on target for Spain.
They have brought in strikers Alvaro Negredo from Sevilla and Stevan Jovetic from Fiorentina, as well as Spanish midfielder Jesus Navas and Brazil midfielder Fernandinho from Shakhtar Donetsk.
The club confirmed his transfer, subject to a medical, in a statement earlier. It declined to say how much City paid for Negredo but Spanish and British media reports put the sum at around 28 million euros ($37 million).
Spain international Negredo, 27, would follow winger Jesus Navas, signed last month from Sevilla by the English club whose new manager has also moved from Spain -- Chilean Manuel Pellegrini from Malaga.
Brazil coach Luiz Felipe Scolari said the result as the perfect fillip as he plots a course to an assault on next year's World Cup finals in Brazil. His counterpart Vicente del Bosque meanwhile admitted Spain had been outclassed on the night. "There are no excuses. Brazil were better than us. We must congratulate them," del Bosque said.
Confounding pre-match expectations, Italy dominated the first half, as Prandelli's decision to deploy a compact 3-4-2-1 system denied Spain's midfielders space in the centre of the pitch. The two wing-backs both played significant roles as well. Marauding right wing-back Christian Maggio went close on three occasions in the first half, while Emanuele Giaccherini h...