Bayer Leverkusen had 15 shots to Bayern Munich's two, but could not find a goal.
Bayer Leverkusen sit eight points behind Bundesliga table toppers Bayern Munich, ahead of their encounter.
Bayer Leverkusen dropped eight points behind league leaders Bayern Munich after a scoreless draw at Wolfsburg on Saturday
Argentine forward Julian Alvarez scored a 90th-minute goal to win the game for Atletico Madrid.
Florian Wirtz scored twice as Bundesliga champions Bayer Leverkusen beat Borussia Moenchengladbach 3-1 on Saturday
The gap at the top of the Bundesliga table is down to four points between Bayern Munich and Bayer Leverkusen.
In 2024, football's uncertainty reached a height it hasn't scaled in many years.
Xabi Alonso's side now have 11 points from six matches, giving Bayern Munich the chance to extend their advantage at the top.
Bayer Leverkusen host AC Milan in the Champions League on Tuesday, hoping for a sparkling performance from star midfielder Florian Wirtz.
Bayern remain top of the Bundesliga table, two points ahead of RB Leipzig and three ahead of Leverkusen.