The France World Cup winner rarely looked capable of finding a breakthrough against a Liverpool team that has been so defensively fragile for much of the campaign.
Liverpool vs Real Madrid LIVE Streaming, Champions League 2025-26 LIVE Telecast: When And Where To Watch
Alexis Mac Allister and Lautaro Martinez bagged braces for Argentina.
Julian Alvarez, Enzo Fernandez, Alexis Mac Allister and Giuliano Simeone sealed an emphatic win for the world champions.
Real Madrid sit 24th in the UEFA Champions League table, the last position to qualify for the knockout stage.
Even Jurgen Klopp, Kenny Dalglish, Bill Shankly and Bob Paisley were unable to muster as many wins at the start of their spells in charge of the Reds.
Liverpool sit two points clear of second placed Manchester City and can extend that gap to five points with a victory over Bournemouth on Sunday.
Spurs are just two points behind Liverpool and claimed an impressive 2-2 draw away to Arsenal last weekend.
Alexis Mac Allister is the first piece in a midfield rebuild for Liverpool, who finished a disappointing fifth in the Premier League.