FC Barcelona announced that Ousmane Dembele will be out for six months after undergoing a hamstring surgery.
Barcelona are second in the La Liga table, two points behind Real Madrid, following their 4-0 win over Sevilla at Camp Nou.
Barcelona restored their five-point lead at the top of La Liga table.
Tottenham only had to match Inter Milan's result at home to PSV Eindhoven, which they did, as the Italians only managed a 1-1 draw themselves.
Ernesto Valverde admitted he did not know the reasons underlying Ousmane Dembele's attitude.
Victory for Barcelona took them back to the top of La Liga, in front of Sevilla and Atletico Madrid, who were each held to 1-1 draws.
Lionel Messi scored a hat-trick as Barcelona put four goals past PSV Eindhoven in the Champions League.