Stan Wawrinka has been struggling to find his best form since returning to the ATP Tour after two operations on his left knee a year ago.
Andy Murray lost 5-7, 6-2, 4-6, 4-6 to Spain's Fernando Verdasco in US Open second round.
Former US Open champions Stan Wawrinka and Svetlana Kuznetsova received wildcards into the event on Tuesday along with two-time Australian Open winner Victoria Azarenka, tournament organisers announced.
A 45-minute rain interruption did little to stop the progress of Rafael Nadal on Thursday at the Toronto Masters as he defeated Stan Wawrinka 7-5, 7-6 (7/4) to reach the quarter-finals.
The three-time Grand champion Wawrinka, currently world No. 224, missed the later part of the last season due to a knee injury that required surgery.
Stanislas Wawrinka, the three-time Grand Slam champion had an obliging opponent in South Africa-born Norrie, who was given a wild card entry after rising to 79th in the rankings.
Novak Djokovic cruised through to the French Open second round in straight sets.
Stan Wawrinka has been plagued by a knee injury and arrived at Roland Garros having won just one match on clay in Geneva last week, his first event in three months.
The 32-year-old world number 12 sat out the second half of 2017 after a knee operation following a first-round exit at Wimbledon in June.
The three-time Grand Slam winner, who defeated Rafael Nadal to win the 2014 Australian Open, has slipped to nine in the world rankings and faces a battle to climb higher after his early round exit.
Swiss Stan Wawinka will undergo a knee surgery and will not be defending his US Open crown.
India's sole ATP event will be held in Pune from next year.
It was Wawrinka's sixth first round loss at the All England Club, although his efforts were hampered by a left knee injury which required an ice pack at the changeovers.
Nadal beats Stan Wawrinka in straight sets to win the men's singles title at Roland Garros for the 10th time.
US Open champion Stan Wawrinka, 32, triumphed in a pulsating four hour 34 minute battle of shot-making and endurance and will target a fourth Slam title on Sunday.
Scot world No 1 brushed aside Karen Khachanov's challenge while 2015 Roland Garros champion from Switzerland defeated Gael Monfils to reach the last-eight stage.
Rome Masters winner Zverev shocked by Fernando Verdasco but world No 1 Murray and former French Open champion Wawrinka advance to the second round.
Roger Federer is in fine form having clinched the Australian Open and Indian Wells so far this year and extended his record to 14-1.