Second-seeded Svetlana Kuznetsova is out of the WTA Tour's Grand Prix SAR after retiring in the third set of her second-round match against Irina-Camelia Begu on Wednesday.
Top-seeded Anabel Medina Garrigues of Spain progressed, meanwhile, with a straight-set win over Mandy Minella of Luxembourg. The Spaniard won 6-2, 6-3.
Former French and U.S. Open champion Kuznetsova breezed through the first set 6-1 against Begu, lost the second in a tiebreaker and was down 3-2 in the decider when she pulled out with an apparent leg injury.
Sixth-seeded Chanelle Scheepers of South Africa was also eliminated in the second round, losing in three sets to Dutch qualifier Kiki Bertens.
Third-seeded Petra Cetkovska and fifth-seeded Simona Halep progressed to the third round with straight-set wins, while qualifier Garbine Muguruza Blanco of Spain beat Patricia Mayr-Achleitner, who also retired after losing the first set 6-4.
Another Spaniard, Laura Pous-Tio, beat Arantxa Rus 6-3, 7-5.
France's Mathilde Johansson beat eighth-seeded Shahar Peer of Israel in three sets, 4-6, 6-3, 6-2 for a place in the third round.