Tiger Woods, who paired with Peyton Manning, showed no rust as they held off a back-nine rally from Phil Mickelson and Tom Brady.
Italy's Francesco Molinari became the first European and only the fourth player ever to go 5-for-5 in a Ryder Cup.
This will be only the second time that the Ryder Cup is staged outside of Britain and Ireland after Spain's Valderrama in 1997.
Tiger Woods was named to the United States' Ryder Cup team on Tuesday as captain Jim Furyk also added veteran Phil Mickelson and in-form Bryson DeChambeau to his line-up.
Shubhankar Sharma closed with a three-over 74 that included five bogeys and just two birdies and left him tied for ninth, six shots adrift.
Henrik Stenson produced a major championship record-equalling round of 63 on the final day to win the British Open at Royal Troon
Arjun Atwal gave away four shots in last three holes and a double bogey for a final two-over 72 to finish tied 52nd
Phil Mickelson had birdies at the third and fifth to dip to two under par on the testing par-70 course. That put him atop the early leaderboard where he was joined by Sweden's Henrik Stenson who birdied the second and third.
From historic champion Jordan Spieth to old-timer Tiger Woods and India's Anirban Lahiri, here are the top five performers of the Augusta Masters.
The task force group will study all aspects of the Ryder Cup process, from how captains are selected to the points system used to determine players, the cutoff dates for deciding rosters, dates for making captains wildcard picks and the selection of vice captains.
The United States were looking to reassert their competitiveness in the biennial inter-continental showdown they once dominated outrageously.
USA's Phil Mickelson and Keegan Bradley, undefeated as a team at Medinah, play the European powerhouse of Rory McIlroy and Sergio Garcia in the opening session of fourballs on Friday at Gleneagles.
Tiger Woods, hindered all season by injury, acknowledged that, all kidding aside, McIlroy had a point in claiming that the 14-time major winner and compatriot Phil Mickelson are in the back nine of their careers.
Tiger Woods is training hard at the gym but admits that he may not be at his best on the golf course just yet.
Tiger Woods and Phil Mickelson will miss the US PGA Tour Championship and Rory McIlroy acknowledges that playing golf can get tougher as one gets older.
Woods won the Jack Nicklaus Award for the 11th time in his career on the back of his five big wins and return to No. 1 in the world this year.
In a feature grouping of the top three players in the world ranking, Mickelson turned in the star performance on Friday morning with a 28 that allowed him to consider - but only briefly - another shot at 59.
The 36-year-old Dufner held off Jim Furyk to win the Wanamaker Trophy by two strokes at the $8 million event.