The defeat for Borussia Dortmund, which leaves them third on 39 points, was also the first time teenage prodigy Erling Braut Haaland failed to score for his new club.
Joachim Loew told the Bayern Munich trio before he names the squad for the friendly against Serbia and the Euro 2020 qualifier.
Germany qualified for Russia with a perfect record of ten wins, but Hummels said the last time the team played well was when they wrapped up qualification late last year.
Chelsea's Antonio Ruediger would be the likely replacement for Hummels.
Mexico created the first upset of the 2018 FIFA World Cup, overcoming defending champions Germany 1-0 in a frenetic Group F game at the Luzhniki Stadium on Sunday.
The craziest time of the footballing calendar has come to an end with clubs spending unprecedented amount of money before the Summer Transfer Window ended late on Wednesday night.
France, who have not lost in the last nine international games, will be eyeing revenge against Germany as they prepare to square-off in the Euro 2016 semi-final
Germany face another test of mettle after their historic Euro 2016 quarter-final win over Italy. However, the world champions are without three stars with defender Mats Hummels suspended, plus striker Mario Gomez and midfielder Sami Khedira injured
Germany could be without the services of Sami Khedira and Mario Gomez due to the injury while they Mats Hummels will miss the semi-final of Euro 2016 due to a one-match suspension
Mats Hummels is struggling with a torn calf muscle which could jeopardise his participation for Germany in Euro 2016.
Barcelona, Chelsea and Manchester United are reported to be interested in signing Mats Hummels who has a market-value of around 35 million euros on the back of outstanding performances at last year's World Cup.
Mats Hummels has long been courted by Manchester United, whose coach Louis van Gaal is seeking a defensive leader with the Premier League giants reported to be willing to meet Dortmund's 35 million euro (US$37.9m) price tag.
Borussia Dortmund lost to SV Werder Bremen, who had been bottom before the victory on Sunday to leave them with just 15 points from 17 matches as they head into the six-week winter break.
A first-half header from Mats Hummels helped Germany become the first team ever to reach four successive World Cup semifinals.
Both Hummels and Podolski missed Germany's 2-1 win over Algeria in the last-16, but are available to face France at Rio de Janeiro's Maracana in the last eight.
Two European football powerhouses, Germany and France, will be eager to iron out several flaws as they fight for a
Fresh from their impressive 3-0 Champions League win over Marseille, Dortmund were set to claim an away point until a disastrous final 10-minute spell.
Having suffered a hamstring injury in April, Goetze was unable to play in Dortmund's 2-1 defeat to Bayern Munich in May's Champions League final at Wembley. Goetze's transfer makes him the second highest transfer in Bundesliga history behind the 40 million euros (US$52m,