Liverpool fell 2-0 at Napoli in the opening match of their Champions League title defence on Tuesday.
Fernando Llorente scored a second-half hat-trick as Tottenham Hotspur advanced into the quarter-finals of the FA Cup with a 6-1 win over lowly Rochdale in a fifth-round replay at a snowy Wembley on Wednesday.
Raheem Sterling scored the fastest goal of the Premier League season as leaders Manchester City got back on track with a 3-1 win against Watford on Tuesday
Fernando Torres' Atletico Madrid travel to Lionel Messi's Barcelona for the season's first first big match of the La Liga
Fernando Llorente, Carlos Tevez and Alvaro Morata scored a brace apiece with Stephan Lichsteiner firing a superb goal as Juventus crushed Parma to record their biggest win since a 7-0 success over Ascoli in December 1983.
Juve's 1-0 win over Udinese leaves them three points clear of Roma with Napoli in third, a further six points adrift.
Juventus, with whom goalkeeper Gianluigi Buffon made his 500th Serie A appearance, now have a two-point cushion on overnight leaders Roma ahead of the capital side's home game against struggling Cagliari on Monday.
Fernando Llorente, Andrea Pirlo and Paul Pogba sent Juve to within one point of table-toppers Roma
Napoli's 2-1 win was their first Serie A victory over the Rossoneri at the San Siro since a side led by Argentine legend Diego Maradona beat Milan in April 1986.
The former Manchester City striker scored on his Serie A debut as the defending champions beat Sampdoria 1-0.